AIDS’in Geçiş Kapıları Kapandı

24 Şubat 2014

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Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission

Alejandro B Balazs, Yong Ouyang, Christin M Hong, Joyce Chen, Steven M Nguyen, Dinesh S Rao, Dong Sung An & David Baltimore

Published online: 09 February 2014 | doi:10.1038/nm.3471

Delivery of HIV-specific neutralizing antibodies by adeno-associated virus vectors—termed vectored immunoprophylaxis (VIP)—has been shown to protect mice or macaques from intravenous infection by HIV or SIV, respectively. David Baltimore and colleagues now report that VIP is also effective at preventing HIV infection after vaginal challenge in humanized mice, suggesting that the approach might limit mucosal transmission between humans.

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